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Direct metabolomic, fluxomic, mitochondrial, and functional assays will be required to determine whether these transcriptional changes correspond to altered biochemical activity
Moreover, carbon monoxide (CO) and heme oxygenase-1 (HO-1) induced IRG1 and A20 expression, which inhibited LPS-stimulated TNF- production in vitro and in a murine sepsis model in vivo, providing further evidence for the anti-inflammatory effects of IRG1 [88]
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UBC-CreERT2;Igf1r fl/fl and Igf1r fl/fl female mice were treated with TMX to induce Igf1r gene deletion ( CreERT2 mice)
et al., 2024), betaine (Cabezn et al., 2016
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